Her father is the late Filipino rapper Francis Magalona and her grandparents are the late actors Pancho Magalona and Tita Duran. Pia Arroyo-Magalona is her mother and her sister is Saab who also joined showbiz in 2007. She is currently taking up Social Science in Ateneo de Manila University.
Maxene's first show as a child was a kiddie show 5 & Up. Then in 2001, she made her appearance in Daddy Di Do Du in which she worked with Vic Sotto. In 2004, the role of Alwina in Mulawin was originally given to her, but she had to turn down the offer in order for her to focus more on her studies at that time. It was later given to Angel Locsin. To date, her biggest break on television is when she was chosen to be one of Richard Gutierrez's leading ladies in Kamandag. After Kamandag, Maxene played Jessa, originally played by Sharon Cuneta, in Sine Novela: Una Kang Naging Akin opposite Wendell Ramos and Angelika dela Cruz.
In 2009, aside from her father's death, Maxene may able to join the casts of SRO Cinema Serye, entitled Ganti, opposite Marvin Agustin and Geoff Eigenmann.
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